IT Essay Example | Topics and Well Written Essays - 750 words - 2

IT - Essay Example Its terms and conditions of service, data use and cookie use policy can be estimated to be about 14, 000 words which run over eight pages. Even for a fast reader, this would take one about two hours to go through all the pages. This could be an associating factor as to why most users simply agree to the terms without agreeing to them, not knowing exactly what right they are handing over to Facebook. In order to ensure customer satisfaction, Facebook could try to edit their terms and conditions to a page or so. At least then, there is a chance of someone actually reading the terms before accepting them unknowingly. Definitively for photos and personal videos uploaded to the site, Facebook has the right to use this content any way they see fit according to the terms and conditions. If people actually knew this, what are the chances that they would probably not upload so many personal photos and videos of themselves online? In addition, the terms state that Facebook can hand over its rights over the user’s content to another organization if needed. Ethically users need to understand how these companies intend to use the content handed over to them and have a say in whether or not it is okay if the organizations have access to this information. Furthermore, the terms and conditions stipulate that eve on deletion or deactivation on a users account, Facebook’s licence over the user’s content shall only come to a cessation in a situation where all of their friends also delete their accounts. The possibility of this ever occurring is next to impossible, which in a way is Facebook taking advantage of user’s negligence (Gopalsamy, 2009). Google is not so popular when one thinks of social networking. It is not hard to imagine that Google+ is probably not the first place where most Google users agreed to their terms and conditions of service. Most users almost certainly signed up through one of Google’s

World Literature Essay Example for Free

World Literature Essay Flaubert’s Madame Bovary was published to critical acclaim and public scandal during Second Empire France (1852–1870). Government censors cited the novel for offending public morality and religion, though prosecution and defense both acknowledged the artist’s achievement. Flaubert was tried and acquitted for a compelling portrait of his heroine’s unhappy marriage, adulterous love affairs, financial ruin, and suicide. The creation of a powerful and profoundly conflicted male imagination, Emma Rouault Bovary is a polarizing figure. She embodies yet challenges archetypal images of women (virgin/mother, madonna/whore, angel/siren) arising from male experience. She calls into question education, marriage, and motherhood, institutions that inculcate these dichotomous views of women. Thomas Manns Death in Venice opens, like Flaubert’s Madame Bovary, on the scene of Aschenbachs creative composure shattered by an unfamiliar nervous excitement. As Aschenbachs mind spins unproductively, we sense immediately that Venice itself will be ultimately just a picturesque exterior, the backdrop to a story whose cardinal events belong to a mental world– to what Mann called â€Å"reality as an operation of the psyche† (Mann 29). Thomas Mann has spared no allusion to suggest that the hero of the story resembles its author at least with regard to his literary production. Yet Aschenbach is said to have achieved in earnest the classical style befitting a conqueror of the abyss the very style which Flaubert parodies in telling the tragic story of Madame Bovarys disillusion and downfall. The societal scandal of Madame Bovary is as remote now as the asceticism of the spirit practiced by Flaubert and Mann, who seem almost self indulgent. Emma seems as boisterous as Aschenbach. With these heroes the novel enters the realm of inactivity, where the protagonists are bored, but the reader is not. Poor Emma, destroyed by usury rather than love, is so vital that her stupidities do not matter. A much more than average sensual woman, her capacity for life and love is what moves us to admire her, and even to love her, since like Flaubert himself we find ourselves in her. Why is Emma so unlucky? If it can go wrong, it will go wrong for her. Flaubert, like some of the ancients, believed there were no accidents. Ethos is the daimon, your character is your fate, and everything that happens to you starts by being you. Rereading, we suffer the anguish of beholding the phases that lead to Emmas self-destruction. That anguish multiplies despite Flauberts celebrated detachment, partly because of his uncanny skill at suggesting how many different consciousnesses invade and impinge upon any single consciousness, even one as commonplace as Emmas. Emmas I is an other, and so much the worse for the sensual apprehensiveness that finds it has become Emma. Whenever Emma is seen in purely sensuous terms, Flaubert speaks of her with a delicate, almost religious feeling, the way Mann speaks of Aschenbach. Flaubert punished himself harshly, in and through Emma, by grimly mixing in a poisonous order of provincial social reality, and an equally poisonous order of hallucinated play, Emmas fantasies of an ideal passion. The mixing in is cruel, formidable, and of unmatched aesthetic dignity. Emma has no Sublime, but the inverted Romantic vision of Flaubert persuades us that the strongest writing can represent ennui with a life-enhancing power. Flaubert despised realism and said so over and over throughout his life; he loved only the absolute purity of art. Madame Bovary has little to do with realism, and something to do with a prophecy of impressionism, but in a most refracted fashion. All of poor Emmas moments are at once drab and privileged. At moments of more overpowering sensuality there even emerges a â€Å"formula† for Emmas sensual intensities, a characteristic style of sensation which, as we know from Flauberts other works, wasnt invented for Emma alone but rather seems to be a basic formula for Flaubertian sensation in general. Sexuality in Flaubert is frequently expressed in terms of a rippling luminosity. â€Å"Here and there,† Flaubert writes as part of his description of Emmas first happy sexual experience (with Rodolphe in the forest near Yonville), â€Å"all around her, in the leaves and on the ground, patches of light were trembling, as if humming-birds, while in flight, had scattered their feathers† (Flaubert 56). Much later, as she lies alone in bed at night enjoying fantasies of running away with Rodolphe, Emma imagines a future in which â€Å"nothing specific stood out: the days, all of them magnificent, resembled one another like waves; and the vision [cela] swayed on the limitless horizon, harmonious, bluish, and bathed in sun† (Flaubert 94). A world heavy with sensual promise (and no longer blindingly illuminated by sexual intensities) is, in Flaubert, frequently a world of many reflected lights blurred by a mist tinged with color.

Teaching Status Report :: Dunn Middle School Education Teaching Essays

Teaching Status Report I cannot believe my time at Dunn Middle School is coming to an end. It finally hit me over Thanksgiving break that in less than two weeks I will not be making the daily drive through Trenton to see my sixth graders. What is more shocking is how upset I am about it. I honestly did not think I would grow so attached to certain students but when I think that I will get to see their faces on a daily basis I get really depressed. I think part of being a teacher is being able to keep a certain distance from the students so attachment does not occur, I clearly failed to do that my first time around. Other than dealing with the feeling of impending loss, JPE is still going really well. Since my last report I have finished my unit plan and I have been observed. I am still teaching mathematics but I base most of my lessons from the textbook and sometimes my cooperating teacher will teach a lesson if he feels it is a difficult concept to comprehend. During the science section of the block p eriod, I serve as a one-on-one tutor and disciplinarian so Mr. Williamson can continue with the science lesson without getting sidetracked. My cooperating teacher and I have a perfect relationship. He never steps on my toes but he never lets me feel alone with the students. I could not have asked for a better cooperating teacher, I am going to miss Mr. Williamson as well. In addition, my authoritative side is slowly improving. I think everyday I gain more control of the class. I think this control was exemplified when we had a substitute teacher for the second time. The first time the class had a substitute teacher they were out of control, they simply refused to listen to me. However, the second time there was a substitute I took control from the beginning of class and kept the students busy and focused the whole class period. My cooperating teacher was impressed that the students were so well behaved for a substitute teacher. I think the difference between these two events was my continued authority over the class throughout the entire period and the amount of work I assigned.

General course on philosophy Essay

The world is comprised of various types of personalities and my personal experience can attest to that. My class is composed of young male and female adults of varying shapes, sizes, heights and colors. During class, I could also imagine that our instructor would perceive us as a sea of hues, all blending together within the space of the classroom. If our instructor did not focus of each one of our faces, it would be impossible for him to differentiate each one of us because we get along well enough to proceed and complete each classroom meeting. Despite the nature of viscosity of our identities, there are also times when certain members of our class would go to opposite directions, especially when philosophical concepts are being discussed. When our instructor would present a controversial topic such as euthanasia, there would be at least three distinct responses from our class. In general, there would be the group that would approve of the concept and the other group would extend an outright disapproval of the topic. The third yet silent group would be that of the neutral ones, who are always known to be nonreactive amidst all the outbursts around them. One should understand that the variations in the responses of the members of our class are not simply comprised of three general reactions. Our instructor is aware that each broad group can be further differentiated according to the principles and beliefs of each individual. For example, if euthanasia were approved in the entire country, the members of the group that is against euthanasia would aggressively react to this. The implementation of euthanasia could be equivalent to the crumbling of their world, as they would envision deaths that are at the mercy of physicians and other healthcare personnel. Looking closer into the reasons behind the disapproval of these individuals to euthanasia may be different for each individual. It is possible that one student disapproves of euthanasia because he is a strong believer of the Catholic religion, which raises the bar in terms of the value of life. Another student may not be in support of the concept of euthanasia because he has lost a loved one through such medical-ethical approach. It is also possible that another student disapproves the topic of euthanasia because his estranged father is a physician who actively participates in such technique, and thus his disagreement is not really about the topic but against his former role model. In order to shed more detail into the finer variations behind the reactions, the instructor should thus know each one of the members of the class. The class is big, as it is mainly a general course on philosophy and thus there are around 200 students in the room. When the instructor walks over to the podium and starts his lecture for the day, our eyes may seem to be tiny lights that would flicker at the very point when he utters a serious topic that needs to be discussed for an hour. He may or may not push some buttons in some of us, resulting in our reactions of support and condemnation. As for the other explosive topics, it may not be a simple button pushing for a number of students, but more of shoving a concept to our faces and asking us to express of thoughts and ideas. The course may be considered as general subject for undergraduate students, yet little do we know that we are unconsciously learning skills on how to analyze concepts. More importantly, these classroom discussions could pave the way to a clear journey for all of us, as we start our movement through an endless tunnel. It may be dark inside this tunnel of the unknown, yet after this long walk, there would be light at the end of the tunnel, leading us to a place that would cushion our identities and provide us slumber. PART II A metaphor can affect a person’s emotions because it allows the writer to symbolize his ideas using things, as well as adjectives, in order that the reader may have a better feel of the narration. A metaphor therefore facilitates in the cognition of an idea, thing or event that the writer wants to describe. This form of language can increase the impact of a narration because it can fully describe thoughts, as well as actions, by the use of transference (Hovecses, 2010). This approach allows the writer to define a certain topic through the use of comparison of two concepts that are generally considered as fully dissimilar yet may be the same in some aspect, viewpoint or perception. A metaphor can affect a person’s emotions because it assists in describing a topic through the use of descriptors of another matter (Wormeli, 2009). It should be understood that the other matter could be something else that is totally different from the topic in mind, yet the application of the descriptors of this matter can increase the weight and impact of the topic in focus. It is probably human nature to employ certain descriptors of one thing in order to provide information on another topic. The use of metaphor allows the narrator to transfer certain features that are unique to one item onto the topic of interest, resulting in a better understanding of the idea that needs to be conveyed. A simple example of a metaphor that could stimulate the emotions of a reader is to use items that are important to the reader, such as the words life, love and world. When a small item means so much to a certain person, the writer could signify this importance by claiming that this small item is equivalent to the life of that person. Once the reader sees this description, he will then feel that the item being presented is indeed so important, thus influencing his emotions to go with the narration. Language can empower or limit the expression of our thoughts because it allows the writer to use analogy in describing a certain topic (Kennedy & Gioia, 2009). The writer is therefore given the freedom to choose which words to employ for his narration. If the writer chooses to use strong words, his ideas are then delivered with great impact, influencing the reader to perceive the same emotions that the writer feels about the topic. On the other hand, a writer may employ subtle words when he feels that there is no need to purposely impart strong emotions regarding a specific matter. Language is therefore a strong tool because it could sway the reader into any direction that the writer wants provide. Every writer has a large reservoir of words that he could employ when describing or explaining a particular topic. In narration, language can be forceful if there is a need to emphasize a certain emotion. Language is empowered through the use of metaphors and other forms of speech because it allows the writer to represent certain topics by analogy (Applebee et al. , 2005). It focuses on describing a certain topic by tapping on the perceptions of the reader through the use of symbolism and analogy. The choice of words that generate a sentence may impact a reader because the writer has the capacity of employ analogy in presenting his ideas. He is capable of identifying one topic by describing features of a separate item, using the latter’s features to emphasize certain points of the former topic. Language is thus a powerful tool that could affect the perceptions and emotions of readers and this is mainly based on the writer’s capacity to apply certain form of speech such as metaphors and similes. Language can take the reader to a place where the writer has been, without physically going to that place. This successful and complete narration of a certain place mainly depends on the capacity of the writer to select words that would fully convey how he feels and sees in the place of interest. It is possible to perceive all the information that we create if we use the correct words that would impart the same effect on the reader. If we would like an audience to feel what we are actually feeling, we can use two general approaches. One approach would be to describe that condition in a straightforward manner, expressing the actual emotion. Another approach would be to employ metaphors, which assist in describing certain topics through the use of analogy. We can therefore present features that are inherent in other matters yet when applied as a descriptor for our topic, it purposefully imparts a sensation in the reader. Metaphors employed as form of speech are thus very helpful in describing and imparting certain emotions that the reader may be directly feel, yet when presented through the use of transference and analogy, could be equivalent to what the writer actually feels. In order to deliver a complete description of a certain topic, we should initially describe the general environment of the topic. For example, if we are describing a person, then the general physical features from a farther point of view should first be presented. These features may include the adjectives such as tall or short in height, lean or heavy in body size and so on. Once this has been provided, finer details of the individual can then be presented, such as wide eyes, or puckered lips or unkempt hair. The organization of the presentation of details of a certain topic is essential in conveying a message to the reader or the audience. This organization of information could significantly influence the reader’s understanding and perception of the topic being presented. If the writer or narrator does not employ this approach, the reader may not fully comprehend the scenario or the topic that is being presented. A disorganized delivery of information to the audience may therefore result in a different understand, emotion and perception of the topic and it may be totally different from what the writer intended to convey. REFERENCES Applebee, A. N. , Bermudez, A. B. & Blau, S. (2005). The language of literature. San Francisco: Holt MacDougal, 1548 pages. Hovecses, Z. (2010). Metaphor: A practical introduction, 2nd ed. London: Oxford University Press, 400 pages. Kennedy, X. J. & Gioia, D. (2009). Literature: An introduction to fiction, poetry, drama and writing. Los Angeles: Longman Publishers, 2256 pages. Wormeli, R. (2009). Metaphors and analogies: Power tools for teaching any subject. New York: Stenhouse Publishers, 264 pages.

Medical Immunology

MEDICAL IMMUNOLOGY & SEROLOGY Terence L. Eday, RMT, MT(ASCPi), MPH College of Medical Technology / Medical Laboratory Science University of Perpetual Help System DALTA Historical Perspective †¢ 1773, Voltaire reported on an ancient Chinese custom where dried and powdered small pox scabs were inhaled †¢ 1798, Edward Anthony Jenner, Smallpox vaccination †¢ 1862, Ernst Haekel, Recognition of phagocytosis 1877, Paul Erlich, recognition of mast cells Historical Perspective †¢ 1879, Louis Pasteur, Attennuated chicken cholera vaccine development †¢ 1883, Ellie Metchnikoff developed the cellular theory of immunity through phagocytosis; phagocytic theory; cellular theory of vaccination †¢ 1885, Pasteur discovered therapeutic vaccination; first report of live â€Å"attenuated† vaccine for rabies Historical Perspective 1888, Pierre Roux & Alexander Yersin, Bacterial toxins (Yersinia pestis) †¢ 1888, George Nuttall, Bactericidal action of blood †¢ 1 890, Emil von Behring and Kitasata introduced passive immunization into modern medicine; humoral theory of immunity †¢ 1891, Robert Koch demonstrated the cutaneous (delayed-type) hypersensitivity †¢ 1894, Richard Pfeiffer, Bacteriolysis Historical Perspective (1 of 6 ) 1895, Jules Bordet, Complement and antibody activity in bacteriolysis †¢ 1900, Paul Ehrlich, responsible for the antibody formation theory †¢ 1901, Karl Landsteiner, A, B, and O †¢ 1901-8, Carl Jensen & Leo Loeb, Transplantable tumors †¢ 1902, Paul Portier & Charles Richet, Anaphylaxis Historical Perspective (1 of 6 ) †¢ 1903, Nicolas Maurice Arthus, discovered the Arthus reaction of intermediate hypersensitivity †¢ 1903, Almroth Wright and Stewart Douglas observed the humoral component, opsonin †¢ 1906, Clemens von Pirquet, coined the word allergy †¢ 1907, Svante Arrhenius, coined the term immunochemistryHistorical Perspective †¢ 1910, Emil von Dungern, & Ludwik Hirszfeld, Inheritance of ABO blood groups †¢ 1910, Peyton Rous, Viral immunology theory †¢ 1914, Clarence Little, Genetics theory of tumor transplantation †¢ 1915-20, Leonll Strong & Clarence Little, Inbred mouse strains Historical Perspective †¢ 1917, Karl Landsteiner, Haptens †¢ 1921, Carl Prausnitz & Heinz Kustner, Cutaneous reactions †¢ 1924, L. Aschoff, Reticuloendothelial system †¢ 1926, Loyd Felton & GH Bailey, Isolation of pure antibody preparation †¢ 1938, John Marrack, Antigen-antibody binding hypothesis Historical Perspective 1936, Peter Gorer, Identification of the H2 antigen in mice †¢ 1940, Karl Landsteiner & Alexander Weiner, Identification of the Rh Antigens †¢ 1941, Albert Coons, Immunofluorescence technique †¢ 1942, Jules Freund & Katherine McDermott, Adjuvants †¢ 1942, Karl Landsteiner & Merill Chase, Cellular transfer of sensitivity in guinea pigs (anaphylaxis) Historical Perspective †¢ 1944, Peter Medwar, Immunological hypothesis of allograft rejection †¢ 1948, Astrid Fagraeus, Demonstration of antibody production in plasma B cells †¢ 1948, George Snell, Congenic mouse lines †¢ 1949, Macfarlane Burnet & Frank Fenner, Immunological tolerance hypothesisHistorical Perspective †¢ 1950, Richard Gershon and K Kondo, Discovery of supressor T cells †¢ 1952, Ogden and Bruton, discovery of agammaglobulinemia (antibody immunodeficiency) †¢ 1953, Morton Simonsen and WJ Dempster, Graft-versus-host reaction †¢ 1953, James Riley & Geoffrey West, Discovery of histamine in mast cells Historical Perspective †¢ 1953, Rupert Billingham, Leslie Brent, Peter Medwar, & Milan Hasek, Immunological tolerance hypothesis †¢ 1955-1959, Niels Jerne, David Talmage, Macfarlane Burnet, Clonal Selection Theory †¢ 1957, Ernest Witebsky et all. Induction of autoimmunity in animals †¢ 1957, Alik Isaacs & Jean Lindemann, Discovery of interferon (cytokine) Hi storical Perspective †¢ 1958-62, Jean Dausset et al. , Human leukocyte antigens †¢ 1959-62, Rodney Porter et al. , Discovery of antibody structure †¢ 1959, James Gowans, Lympocyte circulation †¢ 1961-62, Jaques Miller et al. , Discovery of thymus involvement in cellular immunity †¢ 1961-62, Noel Warner et al. , Disctinction of cellular and humoral immune response Historical Perspective †¢ 1963, Jacques Oudin et al. Antibody isotypes †¢ 1964-68, Anthony Davis et al. , T and B cell cooperation in immune response †¢ 1965, Thomas Tomasi et al. , Secretory immunoglobulin antibodies †¢ 1967, Kimishige Ishizaka et al. , Identification of IgE as the reaginic antibody Historical Perspective †¢ 1971, Donald Bailey, Recombinant inbred mouse strains †¢ 1972, Gerald M. Edelman & Rodney Porter, Identification of antibody molecule †¢ 1974, Rolf Zinkernagel & Peter Doherty, MHC restriction †¢ 1975, Kohler and Milstein, First monoclona l antibodies used in genetic analysisHistorical Perspective †¢ 1984, Robert Good, Failed treatment of severe combined immunodeficiency (SCID, David the bubble boy) by bone marrow grafting †¢ 1985, Tonegawa, Hood et al. , Identification of immunoglobulin genes †¢ 1985-1987, Leroy Hood et al. , Identification of genes for the T cell receptor †¢ 1986, Monoclonal hepatitis B vaccine Historical Perspective †¢ 1986, Mosmann, Th1 versus Th2 model of T-helper-cell function †¢ 1990, Yamamoto et al. Molecular differences between the genes for blood groups O and A and between those for A and B †¢ 1990, NIH team, Gene therapy for SCID using cultured T cells †¢ 1993, NIH team, Treatment of SCID using genetically altered umbilical cord cells Historical Perspective †¢ 1996-1998, Identification of toll-like receptors †¢ 2001, FOXP3, the gene directing regulatory-T-cell development †¢ 2005, Frazer, Development of human papilloma-virus vaccine Th e IMMUNE SYTEM What is Immunology? †¢ Study of the molecules, cells, organs, and systems responsible for the recognition and disposal of foreign (nonself) material †¢ †¦ ow body components respond and interact †¢ †¦desirable and undesirable consequences of immune interactions †¢ †¦ways in which the immune system can be advantageously manipulated to protect against or treat disease What is Immunity? †¢ Latin word â€Å"immunitas†, freedom from †¢ It refers to all mechanisms used by the body as protection against environmental agents that are foreign to the body. †¢ Can be either natural (innate or inborn) or acquired (adaptive) Function of the Immune System †¢ Recognize â€Å"self† from â€Å"nonself† †¢ Defend the body against nonself Physiologic function is to prevent infection and to eradicate established infections (sterilizing immunity) Key Characteristics of the Immune System †¢ Innate immunit y †¢ Primary response †¢ Secondary response and immunologic memory †¢ Immune response is highly specific †¢ Immune system is tolerant of self-antigens †¢ Immune responses against self-antigens can result in autoimmune diseases †¢ Immune responses against infectious agents do not always lead to elimination of the pathogen (HIV/AIDS) Major Principles of Immunity (immune response): Elimination of many microbial agents through the nonspecific protective mechanisms of the innate immune system. †¢ Cues from the innate immune system inform the cells of the adaptive immune system as to whether it is appropriate to make a response and what type of response to make. Major Principles of Immunity (immune response): †¢ Cells of the adaptive immune system display exquisitely specific recognition of foreign antigens and mobilize potent mechanisms for elimination of microbes bearing such antigens. The immune system displays memory of its previous responses. à ¢â‚¬ ¢ Tolerance of self-antigens. Cells of the Immune System †¢ Lymphocytes – occupy the central stage; determines the specificity of immunity †¢ Dendritic cells (DCs) & Langerhan cells †¢ Monocyte/macrophages †¢ Natural killer (NK) cells †¢ Neutrophils †¢ Mast cells & Basophils †¢ Eosinophils †¢ Epithelial and stromal cells – provides anatomic environment (secretion of critical factors that regulate migration, growth and homeostasis) Lymphoid Tissues and Organs Primary Lymphoid Organs Sites where pre-B and pre-T lymphocytes mature into naive T and B cells in the absence of foreign antigen; †¢ Fetal Liver, Adult bone marrow, and thymus The INNATE IMMUNE SYTEM INNATE IMMUNE SYSTEM †¢ relies on germ line-encoded receptors to detect a limited set of microbial structures that are uniquely associated with microbial infection †¢ not a function of a single defined physiologic system; rather, it is a product of multiple a nd diverse defense mechanisms Modules of the Innate Immune System †¢ Surface epithelium The phagocyte system – critical for the defense against both intracellular and extracellular bacteria as well as fungal pathogens; aided by opsonins †¢ Acute phase response and complement – variety of secreted proteins that function in the circulation and in tissue fluids; secreted by the hepatocytes in response to the inflammatory cytokines IL1 and IL-6 Modules of the Innate Immune System †¢ Natural killer (NK) cells are specialized in the elimination of infected host cells and in aiding defense against viral and other intracellular infections through production of cytokines(IFN-? ; regulated by type I interferons (IFN-? /? ) †¢ Mast cells, eosinophils, and basophils are specialized in defense against multicellular parasites, such as helminthes; regulated by several cytokines, including IL-4, IL-5, IL-9, and IL-13 Strategies of Innate Immune Recognition 1. Recog nition of microbial nonself – referred to as pattern recognition, based on the recognition of molecular structures that are unique to microorganisms and not produced by the host 2.Recognition of missing self – based on the recognition of molecules expressed only on normal, uninfected cells of the host Targets of Innate Immune Recognition †¢ PAMPs (pathogen-associated molecular patterns) – molecular structures produced by microbial pathogens, but not by the host organism †¢ PRRs (pattern recognition receptors) – receptors of the innate immune system and represents targets of the innate immune system Targets of Innate Immune Recognition Examples of PAMPs include: (1) LPS of gram-negative bacteria (2) LTA of gram-positive bacteria (3) Peptidoglycans (4) Lipoproteins of bacteria (cell wall) (5) Lipoarabinomannan of mycobacteria (6) dsRNA produced by virus during the infection cycle (7) ? -glucans and mannans found in fungal cell wall Receptors of th e Innate Immune System †¢ Broad categories of PRRs: (1) PRRs that signal the presence of infection; expressed on the cell surface or intracellularly Categories of gene products: a. proteins and peptides that have direct antimicrobial effector functions (antimicrobial peptides and lysozyme) b. nflammatory cytokines and chemokines (TNF, IL-1, IL-8) c. gene products that control activation of the adaptive immune response (MHC, CD80/CD86, IL-12) Receptors of the Innate Immune System †¢ Broad categories of PRRs: (2) Phagocytic (or endocytic) PRRs; expressed on the surface of macrophages, neutrophils, and dendritic cells(DCs) (3) Secreted PRRs (mannan-binding lectin and peptidoglycan-recognition proteins Function: a. activate complement b. opsonize microbials cells to facilitate their phagocytosis c. ccessory proteins for PAMP recognition by transmembrane receptors (TLR) Receptors of the Innate Immune System †¢ Toll-like Receptors – comprise a family of type 1 transm embrane receptors characterized by leucine rich repeats (LRRs) in the extracellular portion and an intracellular TIR (Toll/IL-1 receptor) domain; grouped into two classes: (1) TLRs 1, 2, 4, 5, and 6 are expressed on the plasma membrane and detect bacterial and fungal cell wall components; (2) TLRs 3, 7, and 9 are expressed in endosomal compartments and recognize viral nucleic acidsToll-like receptor 4 (TLR4) †¢ expressed predominantly in the cells of the immune system, including macrophages, DC, neutrophils, mast cells, and B cells †¢ also expressed on endothelial cells, fibroblasts, surface epithelial cells, and muscle cell †¢ Signal transducing receptor for LPS, heat sensitive protein associated with the cell walls of MTB †¢ Together with CD14 shown to mediate responsiveness to the fusion (F) protein of RSVToll-like receptor 2 (TLR2) †¢ Involved in recognition of LTA and peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprot ein, mycobacterial lipoarabinomannan, a phenol-soluble modulin from S. epidermidis, zymosan of yeast cell walls, and lipoglycosylphosphotidylinositol T. cruzi †¢ Also shown to recognize two kinds of atypical LPS: L. interrogans and Porphyromonas gingivitis Toll-like receptor 3 (TLR3) Receptor for dsRNA †¢ Can mediate responses to poly(IC) †¢ Expressed on DCs, macrophages, and surface epithelial cells, including instestinal epithelium †¢ Also expressed in CD8+ DCs Toll-like receptor 7 (TLR7) †¢ Involved in viral recognition and both detect nucleic acids together with TLR9 †¢ Recognizes viral ssRNA (derived from RNA viruses); TLR9 (unmethylated DNA derived from DNA viruses) †¢ Expressed primarily on plasmacytoid dendritic cells †¢ Activated by small antiviral compunds, e. g. imiquinoid †¢TLR7-mediated recognition takes place inside the late lysosomes Toll-like receptor 9 (TLR9) †¢ Involved in the antiviral host defense; especially on r ecognition of DNA viruses (HSV) †¢ Expressed in type-I INF-producing plasmacytoid DCs Phagocytic Receptors †¢ Scavenger receptors – cell-surface glycoproteins that are defined by their ability to bind to modified LDL †¢ Macrophage Mannose Receptor (MR) – type I transmembrane protein expressed primarily in macrophages; involved in phagocytosis of bacterial (MTB, P. eruginosa, K. pneumonia), fungal (S. cerevisae, C. albicans), and protozoan pathogens (P. carinii) Cells of the Innate Immune System †¢ Macrophages – most central and essential functions and have multiple roles in host defense (e. i. â€Å"housekeeping functions†); in red pulp of the spleen, it phagocytose and remove from circulation senescent RBCs †¢ Neutrophils †¢ Mast Cells – best known effectors of allergic response; protective role is by rapid production of TNF-? nd leukotriene B4 (neutrophil recruitement) Cells of the Innate Immune System †¢ Eosino phils – found primarily in the respiratory, intestinal, and genitourinary tracts; contains cationic effector proteins toxic to parasitic worms; poor phagocytes †¢ Dendritic Cells – immature DCs reside in peripheral tissues and are highly active in macropinocytosis and receptor-mediated endocytosis; expresses PRRs and TLRs; have roles in the initiation of adaptive immune response Cells of the Innate Immune System Suface Epithelium – lines the mucosal surfaces of the intestinal, respiratory, and genitourinary tracts provide an important physical barrier The Effector Mechanisms of the Innate Immune System The Major Categories of Antimicrobial Effector Enzymes that hydrolyze components of microbial cell walls Antimicrobial proteins and petides that disrupt the integrity of microbial cell walls †¢ Lysozyme †¢ Chitinases †¢ Phospholipase A2 †¢ †¢ †¢ †¢ †¢ BPI Defensins Cathelicidins Complement Eosinophil cationic protein Mi crobicidal serine proteasesProteins that sequester iron and zinc Enzymes that generate toxic oxygen and nitrogen derivatives †¢ Seprocidins †¢ Lactoferrin †¢ NRAMP †¢ calprotein †¢ Phagocytic oxidase †¢ Nitric oxide synthase †¢ myeloperoxidase The Effector Mechanisms of the Innate Immune System †¢ Lysozyme – a. k. a. muramidase; degrades the peptidoglycan of some gram(+) bacteria; highly concentrated in secretions such as tears and saliva †¢ Chitinases – enzymes that degrade chitin; secreted by activated macrophages and presumably play a role in antifungal defenseThe Effector Mechanisms of the Innate Immune System †¢ Defensins – cationic peptides with a broad spectrum of antimicrobial activities against gram(+) and gram(-) bacteria, fungi, parasites, and some envelope viruses; kill microorganisms by forming pores in the membranes; divided into ? – and ? defensins †¢ ? -defensins – presynthesize d and stored in granules of neutrophils and Paneth cells of the small intestine †¢ ? -defensins – produced by epithelial cells and not stored in cytoplasmic granulesThe Effector Mechanisms of the Innate Immune System †¢ Cathelicidins – active against gram(+) and gram(-) bacteria and fungi; produced in neutrophils and stored as inactive proproteins in the secondary granules †¢ Serprocedins – comprise a family of cationic serine proteases with antimicrobial activity (neutrophil elastase, proteinase 3, cathepsin G, and azurocidin); exert its antimicrobial activity by either perturbation of microbial membranes or by proteolysisThe Effector Mechanisms of the Innate Immune System †¢ Lactoferrin, NRAMP, and Calprotectin – antimicrobial activities are due to the ability to sequester iron and zinc †¢ Lactoferrin – found in the secondary granules of neutrophils, in epithelial secretions (e. i. breast milk), in the intestinal epitheli um of infants, and in airway fluids; bacteriostatic (iron sequestration) and bacteriocidal (perturbation of microbial membranes) The Effector Mechanisms of the Innate Immune System NRAMP (natural resistance-associated macrophage protein) – integral membrane protein that functions as an ion pump in the phagocytic vacuoles of macrophage and neutrophils †¢ Calprotectin – member of the family of calciumbinding proteins; microbial activity is by chelation and sequestration of zinc ion ACUTE PHASE REACTANTS †¢ Soluble factors which are normal constituents that increase or decrease rapidly as produ †¢ Not a function of a single defined physiologic system; rather, it is a product of multiple and diverse defense mechanisms

Jonathans Swifts’ Gulliver’s Travels Essay Essay Example

Jonathans Swifts’ Gulliver’s Travels Essay Essay Example Jonathans Swifts’ Gulliver’s Travels Essay Essay Jonathans Swifts’ Gulliver’s Travels Essay Essay Essay Topic: Trifles In Joanthans Swifts’ Gulliver’s Travels Part IV he uses a certain character to be his perfect illustration for what the human race should be. With this character he so will compare to the lowest of all existences to exemplify all the mistakes of adult male. These characters in his narrative are called the Houyhnhnms. which have a uniquely similar pronunciation to the word worlds. and the Yahoos. who are the evil animals of this peculiar island that Gulliver has washed up upon. Throughout the narrative as Gulliver describes the people of his place to the Houyhnhnms the reader begins to see how Swift shines a visible radiation on all the mistakes that worlds have ; compared to a Godhead. simple and perfect animal as the Houyhnhnms. Gulliver tries to distinct himself from the Yahoos of this land. who he perfectly abhors. by explicating his people’s ways and demoing they have the ability to ground. unlike the Yahoos. The reader easy begins to see what Swift is seekin g to carry through with his Hagiographas. He lets the reader make their ain premises of the human race. but makes the premise really clear. Within the narrative Gulliver describes how â€Å"his eyes had been opened and enlarged his apprehension. which he began to see the actions and passions of adult male in a really different light† ( puchner291 ) . Gulliver begins to see that the thick tegument. excess hair and long nails are simply the lone thing dividing himself from the Yahoos. This oculus gap is precisely what Swift wants his readers to see and see that there are so many ugly mistakes and useless ways of life in their society. The slow pretense of the mistakes within adult male and inquiring of the ways of world are in complete alliance with the thoughts and ways of the Enlightenment. which was in short. to inquiry everything. As Gulliver’s stay on the island continues. this inquiring and scrutiny of every facet of his former life continues every bit good. The Houyhnhnms. or voices of ground. travel on to oppugn the Torahs of Gulliver’s land. One Houyhnhnms states how he can non even contemplate how â€Å"the jurisprudence which was intended for every man’s saving should be any man’s ruin† ( puchner285 ) . Swift takes a deep pang at the governments’ ways of workings at the clip and merely shows how it is anything but merely and does non do any sense. Swift besides makes a singular point in the way of women’s rights. and uses common since to demo how the intervention of adult females of the clip was wholly foolhardy. The voice of a Houyhnhnms explains how it would be â€Å"monstrous in them to give the females a different sort of instruction from the males† ( puchner298 ) . The Houyhnhnms says how this manner holds no logic. because it would go forth one half of their people merely utile for the delivery of kids into the universe and go forth them good for nil else ( puchner298 ) . Swift does non halt at that place and states how irresponsible it would be to non merely go forth this group inadequate but to so swear the attention and upbringing of their kids with these wholly unqualified animals. His ground here is really sound and unmistakable ; how can you anticipate a society to boom if the elevation of adult male is done by the lowest animal of their society. Gulliver tries to turn out to be different organize the Yokel by the fact that he can ground. The Houyhnhnms can see directly through this and one provinces that â€Å"when a animal feigning to ground could be capable of such outrageousnesss. he dreaded lest the corruptness of that module might be worse than ferociousness itself† ( puchner285 ) . Through the Houyhnhnms response Swift dives into the deepnesss of what world is capable of. He tackles how we may hold the power of ground but have abused it to the full extent and alternatively of like the Yahoos caused devastation outwards on the universe we have brought corruptness into the interior existences of our society. Swift’s Hagiographas in Gulliver’s Travels inquiry the full devisings of world and even the inability of people to make bold to inquiry. The Houyhnhnms are Swifts illustration of how worlds should be but even the Houyhnhnms in their perfectness have a mistake. They have no ability to oppugn any facts or speak of â€Å"the thing which is not† . In Swift’s narrative. Gulliver recants how he remembers how difficult it was for him to acquire his maestro to grok the significance of the word sentiment. or how any fact could be brought to inquiry because â€Å"reason taught us to confirm or deny merely where we are certain ; and beyond our cognition we can non make either† ( puchner297 ) . Swift wants the reader to understand that you must non be afraid to set your ideas and what you have been taught all of your life into inquiry. to non fear the unknown. The Houyhnhnms garbage to believe that there are states outside of their ain island. similar to the manner people refuse to believe that there are sentiments and replies other than their ain that could be right. Fleet uses his narrative Gulliver’ s Travels to light the thought that the universe as you know may non be the best of what it could be. merely as the manner narratives have been used to learn kids lessons at a immature age. In Voltaire’s narrative Candide. his chief character Candide is taken on a journey where he is determined to happen his true love Cunegonde. which he is detached signifier in the beginning of the narrative. Through his journey Voltaire has Candide besides in changeless hunt for any adult male that is happier than he. In the narrative Candide has a friend named Pangloss who is a philosopher. In the beginning of this tale Pangloss provinces that â€Å"there can non perchance be an consequence without a cause† and that â€Å"things can non be otherwise than they are. for since everything is made to function an terminal. everything needfully serves the best end† ( puchner356 ) . Voltaire takes these quotation marks throughout the narrative and commits Candide to oppugn it at every opportunity. but is blinded by pure devotedness to what his friend Pangloss has said and continues to force on. Voltaire uses the comparing of two antonyms merely as Jonathan Swift did in G ulliver Travel’s IV. Voltaire uses the land Eldorado in Candide to compare to Westphalia. Eldorado is the illustration of the perfect universe while Westphalia is full of everything that is incorrect with the universe in Voltaire’s sentiment. In this sacred Eldorado Candide and Cacambo witnesses how the people have no desire or wants for the gems that line their streets. He states that â€Å"the kids of this land must be good trained. since they are taught disdain for gold and jewels† ( puchner381 ) . During their dinner with their host at the hotel Candide tries to utilize the gold for payment but in this perfect Eldorado people are gracious and hotels are made and paid for by the province and they do non necessitate any money. Later Candide begins to inquire about faith and finds that this land has the perfect faith where they do non hold monastics that dictate what they do and penalize them if they do non pattern their faith as they say they should ( putchner383 ) . Alternatively Voltaire describes a faith where people are all of the same head and can fre ely pattern their faith ( puchner282 ) . Once Candide meets the male monarch he finds that this perfect land has no parliament for there was no demand and no prisons but they had a gallery full of topographic points to analyze scientific disciplines with mathematical and physical instruments to assist farther cognition ( putchner383 ) . Here you can see how Voltaire is making a universe that has no biass and is surrounded by the overall bettering and good of the people. Although Candide and Cacambo have found the perfect universe they still are non satisfied. This is a major defect in adult male. to go on to desire even after they have everything they need. In response to this. Candide and Cacambo leave and take all the wealths they need that they assume will convey them happiness but alternatively are presented with calamity after calamity that brings them right back to where they began. Candide so by losing everything somehow is reunited with all his friends and they make it to a bantam farm to populate where Pangloss continues to inquiry. He finds a philosopher that he wants to discourse the â€Å"effects and causes. the best of possible universes. the beginning of immorality. the nature of the psyche. and pre-established harmony† ( putchner412 ) all of which are premier illustrations of some of the chief parts that have been in inquiry during the Enlightenment ; but alternatively Pangloss has the door slammed in his face ; similar to the manner adult male refuses to discourse these really same facet. Pangloss still does non halt inquiring inquiries and doing philosophical premises even to the really terminal of the narrative and after all the awful things that had happened to him. Candide so runs into a Turk that states that most of the clip the people who get involved in others concern. perish awfully ( putchner413 ) . The Turk so continues to state Candide that he and his household cultivate their 20 estates â€Å"and the work keeps [ them ] from three great immoralities. ennui. frailty. and poverty† ( putchner413 ) . Candide takes the Turks words really earnestly and shortly sets out his life to copy the Turks and sets up a garden to cultivate. After run intoing all the people throughout his journey he finds this adult male to be the lone individual happier than him and he had found a manner to do life endurable ; so Candide commits to making the same. Voltaire has much to state through his character Pangloss and Martin. about work forces who choose to populate their li ves working. Pangloss states that â€Å"man was non born to take his ease† and Martin remarks that â€Å"working without guess is the lone manner of rendering life endurable. † Candide eventually has everything that he wanted all on their farm but sees that what he wanted and thought is non any longer what he wants or thinks. Cunegonde has lost all her beauty and he does non love her anymore and Pangloss’s theory does non keep a light in Candid’s’ head any longer. He decides to alter his life and halt desiring more and do a life that is focused on one end ; to cultivate his garden and non worry about the trifles amongst the universe. He so sees clearly that he makes his ain felicity and others do non. The garden will maintain him off from the immoralities in which he has met all his life. He will non hold to desire for nutrient and beg. and he will merely hold plenty for what he needs and non what he wants and this will maintain his head busy and off from ennui. Pope’s Hagiographas differ greatly from Swift’s or Voltaire’s. In Pope’s Essay on Man. he uses poesy to exemplify his philosophical points. The start of his essay provinces â€Å"what can we ground but from what we know† ( putchner345 ) . Pope additions the reader’s attending by merely stating that he is merely traveling to analyze Man. This alone is what the Enlightenment was approximately. to take into history all that you thought you cognize and so inquire yourself. is this truly what I know. Pope goes to inquire the inquiry. are we the lone system or existence? He says to merely â€Å"observe how system into system runs† ( putchner345 ) . How can we be the lone universe is the inquiry he wishes to light in us ; if we merely look at our universe we can clearly see that we are excessively a system within a system and possibly we have a intent within this really sphere. He continues to inquire inquiry among inquiry to farther province. why are we the manner we are? And are we the highest being above all on Earth and if so. should we be in this topographic point? We can see where he asks â€Å"if God has placed him wrong† and should we hold the power over the universe that we do ( putchner345 ) . If God has placed us in this high place so shouldn’t we be perfect. but he describes free will by stating that â€Å"man’s every bit perfect as he ought† and that we are every bit good as we let ourselves be ( putchner346 ) . The Essay on Man discusses destiny and why we do non cognize our ain destiny or more so the really page that we are on in life. If â€Å"had he thy ground. would he jump and play† ( putchner346 ) and go on to populate our lives if we knew how it would all terminal. He gives the reply that hope of the unknown is what keeps adult male traveling. He examines the Indian people. a premier illustration of life in the unknown ; for they had no scientific disciplines to allow them see the planets and the existence but still remained to hold God in their civilization. He said they have a â€Å"humbler heaven† before the Europeans came to suppress their land and torture them for their gold ( putchner347 ) . Pope describes to the reader that pride is our mistake and we blame God for everything when we are non happy. Our pride gives us the right to believe that Earth is for our ain usage. He explains â€Å"why has non adult male a microscopic eye† . his response is simple â €Å"that adult male is non a fly† ( putchner347 ) . Pope wants the reader to see that God has made us the manner we are and we are non meant to see that far ; that we are meant to inspect the Earth non to understand the celestial spheres. He ends his essay by stating that â€Å"all partial immorality [ is ] cosmopolitan good† and that â€Å"whatever is. is right† ( putchner351 ) . This really statement was examined greatly by Voltaire’s work Candide and has been examined by many philosophers and minds even to this really present twenty-four hours. The Rape of the Lock is another narrative written by Pope in which he besides uses poesy to make the reader but in my instance went over my caput. He illustrates a beautiful narrative of a miss named Belinda that his great at playing cards and wins the bosom of every adult male and Sylph she comes across. The Sylphs follow Belinda throughout her full twenty-four hours and Pope begins to demo how adult male has no control over anything that happens ; whether that may be the folding of her arms or the safety of Belinda. Pope may be go oning his theory that adult male has his ain destiny but that he can non cognize it and certain Powers that are out of our understand command our twenty-four hours to twenty-four hours life. That this is the manner things are and it is in our best ability to be happy with the life we are given. Even the just Belinda blessed with all the beauty in the universe is non spared by destinies manus. The loss of her strand of hair in the terminal may resemble the loss of virtuousness and her pride for even the perfect can be brought down. Plants CitedPuchner. Martin. Suzanne Akbari. Wiebke Denecke. Vinay Dharwadke. and Barbara Fuchs. The Norton Anthology of World Literature. 3rd erectile dysfunction. Vol. D. New York. London: W. W. Norton A ; Company. 2012. 269-413. Print.

Italian Women Artists essays

Italian Women Artists essays Prior to the fifteenth century, very few works of art were signed and virtually no information on their artists, male or female, was recorded. However, beginning in the early Renaissance, the identities of artists and their stories begin to be preserved. Any study of the art of this period will undoubtedly include the study of the lives and works of the great masters such as Raphael, Donatello, Michelangelo, and Leonardo da Vinci, but rarely is there any mention of their female contemporaries. While these men were unquestionably some of the greatest artists who ever lived, no study could be complete without an examination of the lives and influence of women during this period. Fourteenth Century Italy was the first area to show a shift in culture from the feudal system of the Middle Ages to an urban economy based on commerce and the accumulation of wealth. This new cultural system was very conducive to the development of wide spread interest in the fine arts. While this increasing interest in the arts and the development of capitalism opened many new possibilities for Renaissance men, it often left women with less power than they had had under the feudal system (Kelly-Gadol, 1974). Beginning in the Middle Ages and continuing through the seventeenth century, artists were usually taught their crafts through apprenticeships. However, it was not proper for women to travel or be trained outside of the home, therefore most women were unable to pursue formal artistic training. The only way for an early Renaissance woman to receive artistic training was for her to join a nunnery. This gave unmarried women the opportunity to escape the male-dominated society and allowed them to learn and practice their art. Thus, the few women artists whose names are known from the fifteenth century were nuns such as Caterina dei Vigri (1413-1463) (St. Catherine of Bologna). Unfortunately, by the end of the fifteenth century, due to the Counter-Reformation,...

The History and Invention of Water Skiing

The History and Invention of Water Skiing In June 1922, 18-year-old adventurer Ralph Samuelson of Minnesota proposed that if you could ski on snow, then you could ski on water. Ralph first attempted water skiing on Lake Pepin in Lake City, Minnesota, towed by his brother Ben. The brothers experimented for several days until July 2, 1922, when Ralph discovered that leaning backward with ski tips up leads to successful water skiing. Unwittingly, Samuelson had invented a new sport. The First Water Skis For his first skis, Ralph tried  snow skis on Lake Pepin, but he sank. Then he tried barrel staves, but he sank again.  Samuelson realized that with the speed of the boat - a top speed of less than 20 mph - he needed to fashion some type of ski that would cover more water surface area.  He bought two 8-foot-long, 9-inch-wide planks, softened one end of each  and shaped them by curving the ends up, held with vice grips to keep the ends up and in place. Then, according to Vault magazine, he fastened a leather strap in the middle of each ski to hold his feet in place, bought 100 feet of sash cord to use as a tow rope and had a blacksmith make him an iron ring, 4 inches in diameter, to serve as a handle, which he insulated with tape. Success on  the Water After several failed attempts at getting up and out of the water,  Samuelson finally discovered the successful method was to lean backward in the water with ski tips pointing upward. After that, he spent over 15 years performing ski shows and teaching people in the United States how to ski. In 1925 Samuelson  became the worlds first water ski jumper, skiing over a partly submerged diving platform that had been greased with lard. Water Ski Patents   In 1925, Fred Waller of Huntington, New York, patented the first water skis, called Dolphin AkwaSkees,  made out of kiln-dried mahogany - Waller had first skied on Long Island Sound in 1924. Ralph Samuelson never patented any of his water skiing equipment. For years,  Waller had been credited as  the inventor of the sport. But, according to Vault,  clippings in Samuelsons scrapbook and on file with the Minnesota Historical Society were beyond dispute, and in February 1966 the AWSA officially recognized him [Samuelson] as the father of waterskiing. Water Ski Firsts With the invention now a popular sport, the first ski shows were held at the Century of Progress in Chicago and the Atlantic City Steel Pier in 1932. In 1939 the American Water Ski Association (AWSA) was organized by Dan B. Hains, and the first National Water Ski Championships were held on Long Island in the same year. In 1940 Jack Andresen invented the first trick ski - a shorter, finless water ski. The first World Water Ski Championship was held in France in 1949. The National Water Ski Championships were broadcast on national television for the first time at Callaway Gardens, Georgia, in 1962, and the MasterCraft ski boat company  was founded in 1968.  In 1972 water skiing was an exhibition sport at the Olympic Games in Keil, Germany, and in 1997, the  U.S. Olympic Committee recognized  water skiing as a Pan American Sports Organization and AWSA as the official national governing body.

Based on your current achievements and interests, describe the kind of Essay

Based on your current achievements and interests, describe the kind of work that you plan to be in 10years, both in your career and in your community - Essay Example I would describe myself as a sporty person whom everybody can feel good with. I know that I am a down-to-earth person, with no attitude or behavioral problems. My parents have given me many valuable lessons of life, of which the greatest one is that commitment to your field of interest is crucial to be successful. Truth is my principle, and I stick to my principles no matter what happens. Besides, I am a very committed person, and I love to play different sports in my free time. I remember that when I was a little kid, I would play baseball and badminton all day long with my neighbor. Since then, I have developed such passion regarding sports that has not vanished even today. When I was growing up, my grandmother would tell me stories of eminent players who played for the name of their countries and earned awards. I would always become greatly inspired by such players. I wanted to be like them. I wanted to coach those kids who needed help in playing. I had many badminton and baseball kits in my childhood, and I remember how much I had cried one day when my baseball kit got stolen. The memories of childhood are still in my mind, and I cannot forget how I would yearn to play with children instead of watching television. My achievements and my passion toward sports clearly show that I am a dedicated sportsman. Hence, I would want to go into the field of sports after completing my engineering degree. In the next ten years, I see myself playing in the NFL. I always loved how volunteers would come to help me and other kids while we played in the sports field. I have always wanted to do the same with the kids of my community when I grow up. Even if I enter into the engineering field, I would not leave the ambition of helping kids in sports. If I go into an engineering field, I would work in one of the plants along a nearby river. Hence, I am sure to state that in the next ten years, I see myself as a great player

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Strategic Change Management (Ansewr 6 questions) - Assignment Example High attrition rate and staff downsizing strategy of Airline company’s crates impact on defence mechanism of Airline staff. Southwest Airlines has applied clarity system as a part of Kurt Lewins Change Management Model to decrease resistance about newly implemented software system. The company has changed existing Microsoft Excel reporting pattern by implementing Hyperion Essbase model of financial budgeting. The company did the change in order to decrease overall reporting cost. The logic model of synergy theory describes sustainable change as participation multi level actors (local and global, top level, mid level and ground level management). This model not only increases communication scope but decreases change resistance also. British Airways used Kurt Lewin’s change management model in order to create positive impact on their business policy. In the unfreeze stage they downsized the workforce in order to decrease hierarchical levels. In the change phase British Airways altered internal system and provided incentives to absorb the shock effect. In the refreeze stage BA integrated customer satisfaction with individual objective of key members of organizational hierarchy. They refurbished uniform of staff and aircraft design as a part of change management process. The market demand for Airline industry has been dented due to sovereign debt crisis and economic recession. Airline industry has lost more than $25bn (Â £16bn) in last ten years (Milmo, Topham, and Roberts, 2012). Companies are competing with each other in order to achieve competitive edge such as low cost service delivery, fast service delivery, expanded destination service, fleet size and many others. For example, Southwest Airlines has achieved the competitive edge of lowest fare in comparison to other players in the market. The new airline group formed by the merger is the sixth largest airline service in the world in terms of

Strategic Corporate Finance Essay Example | Topics and Well Written Essays - 1000 words

Strategic Corporate Finance - Essay Example An investor must be paid some price for this sacrifice (Brigham & Weston, 2009). So the future value of the dollar-assuming a positive rate of interest-will always be higher than its present value. Another reason for interest being charged on capital is that capital is one of the factors of production that can give access to men, materials and machinery, help automate and speed up processes and productivity in a short time and this is why the demand for capital attracts a price called the interest rate (Rao, 2011). Why is it Important for Financial Managers to Understand the Concept of Time Value of Money? Finance is the lifeblood of business and industry. Everything from running the day to day operations of an enterprise to meeting financial needs for future plans requires money. In fact investing surplus funds to get the best possible returns as well as keeping sufficient liquidity in the asset and liability mix is a key function of financial managers. They look at both present and future plans of the business and consider how to achieve these in the light of financial requirements (Crosson & Needles, 2008). This is why an understanding of the time value of money is of key importance to financial managers. They can match the funding and investment portfolios of the enterprise to get the best returns (Mathur, 1979). Calculations of the Future Value: a. $54,298 if invested for five years at a 7% interest rate FV= PV (1 + r)t FV= 52948(1 + 0.07)5 FV= 52948(1.07)5 FV= 52948 x 1.225 FV = $ 64,861. b. $99,112 if invested for three years at a 4% interest rate FV= PV (1 + r)t FV= 99112(1 + 0.04)3 FV= 99112(1.04)3 FV= 99112 x 1.125 FV = $ 111,501. c. $121,124 if invested for seven years at an 2% interest rate FV= PV (1 + r)t FV= 121124(1 + 0.02)7 FV= 112124(1.02)7 FV= 112124 x 1.149 FV = $128,830. d. $929,129 if invested for ten years with a 0.9% interest rate FV= PV (1 + r)t FV= 929129(1 + 0.009)10 FV= 929129(1.009)10 FV= 929129 x 1.09373 FV = $1,016,216. Calculation s of the Present Value: a. $455,126 to be received three years from now with a 4% Interest rate PV= FV/(1 + r)t PV= 455126/(1 + 0.04)3 PV= 455126/(1.04)3 PV= 455126 x 0.889 PV = $404,607. b. $289,231 to be received five years from now with a 5% interest rate PV= FV/(1 + r)t PV= 289231/(1 + 0.05)5 PV= 289231/(1.05)5 PV= 289231 x 0.864 PV = $249,896. c. $921,000 to received two years from now with a 12% interest rate PV= FV/(1 + r)t PV= 921000/(1 + 0.12)2 PV= 921000/(1.12)2 PV= 921000 x 0.797 PV = $734,037. d. $278,111 to be received eight years from now with a 1% interest rate. PV= FV/(1 + r)t PV= 278111/(1 + 0.01)8 PV= 278111/(1.01)8 PV= 278111 x 0.923 PV = $256,696. Suppose you are to receive a stream of annual payments (also called an "annuity") of $309,723 every year for three years starting this year. The interest rate is 4%. What is the present value of these three payments? PV of Annuity= PVA= A(PVFA)i,n PVA=309723(PVFA).04,3 PVA=309723 x 2.775 PVA=$859,481.32 Suppose you are to receive a payment of $239,201 every year for three years. You are depositing these payments in a bank account that pays 2% interest. Given these three payments and this interest rate, how much will be in your bank account in three years? FV of Annuity= FVAn=A(FVFA)i,n FVA=239201(FVFA).02,3 FVA=239201 x 3.060 FVA=$731,955. Evaluation of Module 2 Case Assignment The Module 2 case assignment gave me an opportunity to learn about the time value of

Critically evaluate at least two different theories of autism Essay

Critically evaluate at least two different theories of autism - Essay Example And while in the mentioned films the problem of integration of people with autism in society is considered, modern medical researchers are not less concerned with the problem of uncovering the biological causes of autism. But this task is far from being an easy one, as can be judged from the fact that there are currently several tens of various theories that pretend if not to discover the single cause of autism, but at least to offer clues as to autism`s most fundamental physiological roots (Novartis Foundation, 2003, pp.8-9). In this regard, let us overview and critically evaluate several theories of autism, each of which highlights different biological mechanisms that are suspected to lead to this developmental disorder. In general, theories of autism emergence can be divided into large categories. One group of theories, such as for instance opioid excess theories, views autism as a consequence of certain inborn abnormalities; another group, like for example viral infection theories or the approach that accentuates the increased intestinal permeability, links autism with some acquired abnormalities; and there is a group of theories that aims to investigate the possibility of connection between autism and external factors of influence, such as the effects produced by certain types of vaccines. As can be immediately seen, the range of possible causes of autism is quite diverse. To better asses each type of approaches to autism study, we will overview the mentioned opioid excess theories, the viral infection theory, and the theory of the autism origin due to standard vaccinations of children. The opioid excess theories of autism emphasise abnormalities in the complex workings and influences of opioids and opioid-like substances in the human organism, and particularly in the brain. Natural opioids produce various effects upon the processes of hormonal regulation, especially if there is an

Cosmopolitan magazine sells sex to its audience Essay

Cosmopolitan magazine sells sex to its audience - Essay Example The rest of the paper analyzes aspects of the issue and the magazine in general, including format, audience, coverage by subjects and content, advertising, ideologies and cultural stories, and the overall worth of the magazine to pop culture (Hearst Communications). II. Format The standard page size of the print magazine is 290 x 210 millimeters, and within this page all of the contents of the magazine are bound, including all articles, photos, advertisements and the cover and back pages (â€Å"Cosmopolitan Specifications†). What differentiates Cosmopolitan from other print magazines is presence of digital and online formats, to complement the print format that is widely distributed physically. The digital versions are identical to the print ones, except that they are made available via the popular digital media distribution formats, namely the iPad, the Kindle, and the Nook. These are on top of the online versions to be had via the web browsers, which include the preview vers ion on which this analysis is largely based (Hearst Communications). The layout of the front page is centered on the model for the month; in this case the picture of Kate Upton is front and center in the front page, with the Cosmopolitan banner in yellow, and the rest of the cover background in pink. Around the cover photo are the headlines of the different stories featured on the magazine issue, surrounding Kate Upton. The emphasis of the articles is on the readers' egoistic and sensual interests. A key feature of every issue, of course, is the pictorial of the model of the month. In this case, the pictorial of Kate Upton for the November issue is already included in the website. The website pictorial is notable for including advertisements for featured products, in this case lingerie. The lingerie worn by Kate Upton has corresponding brands and prices. This way of advertising is a common format for the magazine, more of which shall be discussed in the advertising section of this p aper (Hearst Communications). Among the key defining aspects of Cosmo are the tones that are geared towards women in terms of color, and the use of the word â€Å"sex† in capital letters at least one time in the cover page every issue, in the most prominent part of the magazine cover. Past cover pages confirm this, with at least several article titles bearing the word sex in them. The format is always that of a glossy magazine with the topics inevitably including sex and sex stories purveyed by the magazine all over the world (Zimmerman). III. Audience The audience, it is clear, is made up of women buyers and consumers of the magazine, fans of popular culture, and media in general. The semi-naked photos of Kate Upton likewise invite the males as an alternative audience, even as the primary focus of the articles and the advertisements are women. An analysis reveals that general circulation is about 3 million, with an audience base that extends to 64 countries, corresponding to the 64 international versions that are made available to different audiences by nationality on a monthly basis. The audience extends from teenagers to adult women in different parts of the world, with emphasis on the middle class (Zimmerman). IV. Subjects Covered, Content Summary As discussed in the format, the subjects covered revolve around female grooming and beauty interests, the opposite sex from the point of view of women, and always

Critically evaluate at least two different theories of autism Essay

Critically evaluate at least two different theories of autism - Essay Example And while in the mentioned films the problem of integration of people with autism in society is considered, modern medical researchers are not less concerned with the problem of uncovering the biological causes of autism. But this task is far from being an easy one, as can be judged from the fact that there are currently several tens of various theories that pretend if not to discover the single cause of autism, but at least to offer clues as to autism`s most fundamental physiological roots (Novartis Foundation, 2003, pp.8-9). In this regard, let us overview and critically evaluate several theories of autism, each of which highlights different biological mechanisms that are suspected to lead to this developmental disorder. In general, theories of autism emergence can be divided into large categories. One group of theories, such as for instance opioid excess theories, views autism as a consequence of certain inborn abnormalities; another group, like for example viral infection theories or the approach that accentuates the increased intestinal permeability, links autism with some acquired abnormalities; and there is a group of theories that aims to investigate the possibility of connection between autism and external factors of influence, such as the effects produced by certain types of vaccines. As can be immediately seen, the range of possible causes of autism is quite diverse. To better asses each type of approaches to autism study, we will overview the mentioned opioid excess theories, the viral infection theory, and the theory of the autism origin due to standard vaccinations of children. The opioid excess theories of autism emphasise abnormalities in the complex workings and influences of opioids and opioid-like substances in the human organism, and particularly in the brain. Natural opioids produce various effects upon the processes of hormonal regulation, especially if there is an

Does Successful Internal Communication at the Time of Change Result in Coursework

Does Successful Internal Communication at the Time of Change Result in a Motivated Workforce - Coursework Example Information Technology provides several options for this. E-mails, intranets and other innovations help in meeting the high demand of communication during such time of alteration within the organization (Wojtecki and Peters, 2000). Face to face communication also might help a lot to sort out the differences. There have been mostly separate studies about leadership and grapevine communication. According to McKenna (2000), leadership is an art that can get the optimum work required for the organization. The leader also communicates the organization's goals to his team members. He does not discuss the communication that is more important between the leader and the team and the effectiveness when such communication occurs in an informal way that leads to more interaction and hence develops a bond with each employee and all together leads to commitment.  Most of the studies so far have taken the formal side into consideration. In Contemporary issues in management and organizational beha vior (Peter, Poole and Jones, 2005), the whole cycle of Team-leadership has been portrayed in analyzing group decision- making and learning. Later, a global perspective has been given. According to Robert E. Hoskisson, â€Å"Organisational Structure specifies the firm’s formal reporting relationships, procedures, controls, and authority and decision-making processes.† (Hoskisson, 2008, p.100) This accrues to the basic framework of assigning roles, allocation of resources and provides a basis for cooperation, coordination, and communication among the organizational hierarchy. (Hoskisson, 2008). Harris and Hartman discuss the problems of Grapevine. According to them, it is not a dependable source and cannot provide full information and may be distorted. (Harris & Hartman, 2002).  

Jonathans Swifts’ Gulliver’s Travels Essay Example for Free

Jonathans Swifts’ Gulliver’s Travels Essay In Joanthans Swifts’ Gulliver’s Travels Part IV he uses a certain character to be his perfect example for what the human race should be. With this character he then will compare to the lowest of all beings to illustrate all the faults of man. These characters in his story are called the Houyhnhnms, which have a uniquely similar pronunciation to the word humans, and the Yahoos, who are the evil beasts of this particular island that Gulliver has washed up upon. Throughout the story as Gulliver describes the people of his home to the Houyhnhnms the reader begins to see how Swift shines a light on all the faults that humans have; compared to a divine, simple and perfect creature as the Houyhnhnms. Gulliver tries to distinct himself from the Yahoos of this land, who he absolutely abhors, by explaining his people’s ways and showing they have the ability to reason, unlike the Yahoos. The reader easily begins to see what Swift is trying to accomplish with his writings. He lets the reader make their own assumptions of the human race, but makes the assumption very clear. Within the story Gulliver describes how â€Å"his eyes had been opened and enlarged his understanding, which he began to view the actions and passions of man in a very different light†(puchner291). Gulliver begins to see that the thick skin, extra hair and long nails are merely the only thing separating himself from the Yahoos. This eye opening is exactly what Swift wants his readers to experience and see that there are so many despicable faults and useless ways of life in their society. The slow dissembling of the faults within man and questioning of the ways of mankind are in complete alignment with the ideas and ways of the Enlightenment, which was in short, to question everything. As Gulliver’s stay on the island continues, this questioning and examination of every aspect of his former life continues as well. The Houyhnhnms, or voices of reason, go on to question the laws of Gulliver’s land. One Houyhnhnms states how he cannot even contemplate how â€Å"the law which was intended for every man’s preservation should be any man’s ruin† (puchner285). Swift takes a deep stab at the governments’ ways of workings at the time and simply shows how it is anything but just and does not make any sense. Swift also makes a remarkable point in the direction of women’s rights, and uses common since to show how the treatment of women of the time was entirely reckless. The voice of a Houyhnhnms explains how it would be â€Å"monstrous in them to give the females a different kind of education from the males† (puchner298). The Houyhnhnms says how this way holds no logic, because it would leave one half of their people only useful for the bringing of children into the world and leave them good for nothing else (puchner298). Swift does not stop there and states how irresponsible it would be to not only leave this group inadequate but to then trust the care and upbringing of their children with these completely incompetent creatures. His reason here is very sound and unmistakable; how can you expect a society to flourish if the raising of man is done by the lowest creature of their society. Gulliver tries to prove to be different form the Yahoos by the fact that he can reason. The Houyhnhnms can see straight through this and one states that â€Å"when a creature pretending to reason could be capable of such enormities, he dreaded lest the corruption of that faculty might be worse than brutality itself† (puchner285). Through the Houyhnhnms response Swift dives into the depths of what humankind is capable of. He tackles how we may have the power of reason but have abused it to the full extent and instead of like the Yahoos caused destruction outwards on the world we have brought corruption into the inner beings of our society. Swift’s writings in Gulliver’s Travels question the entire makings of humankind and even the inability of people to dare to question. The Houyhnhnms are Swifts example of how humans should be but even the Houyhnhnms in their perfectness have a fault. They have no ability to question any facts or speak of â€Å"the thing which is not†. In Swift’s story, Gulliver recants how he remembers how hard it was for him to get his master to comprehend the meaning of the word opinion, or how any fact could be brought to question because â€Å"reason taught us to affirm or deny only where we are certain; and beyond our knowledge we cannot do either† (puchner297). Swift wants the reader to understand that you must not be afraid to put your thoughts and what you have been taught all of your life into question, to not fear the unknown. The Houyhnhnms refuse to believe that there are nations outside of their own island, similar to the way people refuse to think that there are opinions and answers other than their own that could be right. Swift uses his story Gulliver’s Travels to ignite the idea that the world as you know may not be the best of what it could be, just as the way stories have been used to teach children lessons at a young age. In Voltaire’s story Candide, his main character Candide is taken on a journey where he is determined to find his true love Cunegonde, which he is separated form in the beginning of the story. Through his journey Voltaire has Candide also in constant search for any man that is happier than he. In the story Candide has a friend named Pangloss who is a philosopher. In the beginning of this tale Pangloss states that â€Å"there cannot possibly be an effect without a cause† and that â€Å"things cannot be otherwise than they are, for since everything is made to serve an end, everything necessarily serves the best end† (puchner356). Voltaire takes these quotes throughout the story and commits Candide to question it at every chance, but is blinded by pure devotion to what his friend Pangloss has said and continues to push on. Voltaire uses the comparison of two opposites just as Jonathan Swift did in Gulliver Travel’s IV. Voltaire uses the land Eldorado in Candid e to compare to Westphalia. Eldorado is the example of the perfect world while Westphalia is full of everything that is wrong with the world in Voltaire’s opinion. In this sacred Eldorado Candide and Cacambo witnesses how the people have no desire or wants for the jewels that line their streets. He states that â€Å"the children of this land must be well trained, since they are taught contempt for gold and jewels† (puchner381). During their dinner with their host at the hotel Candide tries to use the gold for payment but in this perfect Eldorado people are courteous and hotels are made and paid for by the state and they do not need any money. Later Candide begins to ask about religion and finds that this land has the perfect religion where they do not have monks that dictate what they do and punish them if they do not practice their religion as they say they should (putchner383). Instead Voltaire describes a religion where people are all of the same mind and can freely practice their religion (puc hner282). Once Candide meets the king he finds that this perfect land has no parliament for there was no need and no prisons but they had a gallery full of places to study sciences with mathematical and physical instruments to help further knowledge (putchner383). Here you can see how Voltaire is creating a world that has no prejudices and is surrounded by the overall bettering and good of the people. Although Candide and Cacambo have found the perfect world they still are not satisfied. This is a major flaw in man, to continue to want even after they have everything they need. In response to this, Candide and Cacambo leave and take all the riches they need that they assume will bring them happiness but instead are presented with tragedy after tragedy that brings them right back to where they began. Candide then by losing everything somehow is reunited with all his friends and they make it to a tiny farm to live where Pangloss continues to question. He finds a philosopher that he wants to discuss the â€Å"effects and causes, the best of possible worlds, the origin of evil, the nature of the soul, and pre-established harmony† (putchner412) all of which are prime examples of some of the main parts that have been in question during the Enlightenment; but instead Pangloss has the door slammed in his face; similar to the way man refuses to discuss these very same aspect. Pangloss still does not stop asking questions and making philosophical assumptions even to the very end of the story and after all the terrible things that had happened to him. Candide then runs into a Turk that states that most of the time the people who get involved in others business, perish terribly (putchner413). The Turk then continues to tell Candide that he and his family cultivate their 20 acres â€Å"and the work keeps [them] from three great evils, boredom, vice, and poverty† (putchner413). Candide takes the Turks words very seriously and soon sets out his life to imitate the Turks and sets up a garden to cultivate. After meeting all the people throughout his journey he finds this man to be the only person happier than him and he had found a way to make life bearable; so Candide commits to doing the same. Voltaire has much to say through his character Pangloss and Martin, about men who choose to live their lives working. Pangloss states that â€Å"man was not born to take his ease† and Martin comments that â€Å"working without speculation is the only way of rendering life bearable.† Candide finally has everything that he wanted all on their farm but sees that what he wanted and thought is not anymore what he wants or thinks. Cunegonde has lost all her beauty and he does not love her anymore and Pangloss’s theory does not hold a light in Candid’s’ mind anymore. He decides to change his life and stop wanting more and make a life that is focused on one goal; to cultivate his garden and not worry about the trifles amongst the world. He then sees clearly that he makes his own happiness and others do not. The garden will keep him away from the evils in which he has met all his life. He will not have to want for food and beg, and he will only have enough for what he needs and not what he wants and this will keep his mind busy and away from boredom. Pope’s writings differ greatly from Swift’s or Voltaire’s. In Pope’s Essay on Man, he uses poetry to illustrate his philosophical points. The start of his essay states â€Å" what can we reason but from what we know†(putchner345). Pope gains the reader’s attention by simply saying that he is just going to examine Man. This alone is what the Enlightenment was about, to take into account all that you thought you knew and then ask yourself, is this really what I know. Pope goes to ask the question, are we the only system or universe? He says to just â€Å"observe how system into system runs†(putchner345). How can we be the only world is the question he wishes to ignite in us; if we just look at our world we can clearly see that we are too a system within a system and perhaps we have a purpose within this very sphere. He continues to ask question among question to further state, why are we the way we are? And are we the highest being above all on earth and if so, should we be in this place? We can see where he asks â€Å"if God has placed him wrong† and should we have the power over the world that we do (putchner345). If God has placed us in this high position then shouldn’t we be perfe ct, but he describes free will by saying that â€Å"man’s as perfect as he ought† and that we are as good as we let ourselves be (putchner346). The Essay on Man discusses fate and why we do not know our own fate or more then the very page that we are on in life. If â€Å"had he thy reason, would he skip and play† (putchner346) and continue to live our lives if we knew how it would all end. He gives the answer that hope of the unknown is what keeps man going. He examines the Indian people, a prime example of living in the unknown; for they had no sciences to let them see the planets and the universe but still remained to have God in their culture. He said they have a â€Å"humbler heaven† before the Europeans came to conquer their land and torment them for their gold (putchner347). Pope describes to the reader that pride is our error and we blame God for everything when we are not happy. Our pride gives us the right to think that earth is for our own use. He explains â€Å"why has not man a microscopic eye†, his response is simple â€Å"that man is not a fly† (putchner347). Pope wants the reader to see that God has made us the way we are and we are not meant to see that far; that we are meant to inspect the earth not to understand the heavens. He ends his essay by saying that â€Å"all partial evil [is] universal good† and that â€Å"whatever is, is right† (putchner351). This very statement was examined greatly by Voltaire’s work Candide and has been examined by many philosophers and thinkers even to this very present day. The Rape of the Lock is another story written by Pope in which he also uses poetry to reach the reader but in my case went over my head. He illustrates a beautiful story of a girl named Belinda that his great at playing cards and wins the heart of every man and Sylph she comes across. The Sylphs follow Belinda throughout her entire day and Pope begins to show how man has no control over anything that happens; whether that may be the folding of her sleeves or the safety of Belinda. Pope may be continuing his theory that man has his own fate but that he cannot know it and certain Powers that are out of our understand control our day to day life. That this is the way things are and it is in our best ability to be happy with the life we are given. Even the fair Belinda blessed with all the beauty in the world is not spared by fates hand. The loss of her strand of hair in the end may resemble the loss of virtue and her pride for even the perfect can be brought down. Works Cited Puchner, Martin, Suzanne Akbari, Wiebke Denecke, Vinay Dharwadke, and Barbara Fuchs. The Norton Anthology of World Literature. 3rd ed. Vol. D. New York, London: W. W. Norton Company, 2012. 269-413. Print.

Example of Business Contract

Example of Business Contract 1. Your Relationship with PCFS Solutions. A. Introduction. The sale and performance of Professional Services (defined below) hereunder is subject to the terms of this Professional Services Agreement (the Agreement) between you (hereinafter you or Client) and PCFS Solutions, Inc. and its affiliates (hereinafter PCFS Solutions). PCFS Solutionss sale and performance of Professional Services under this Agreement shall be solely for Clients own internal use and not for resale. B. Definitions. Deliverables means the tangible and intangible materials, including reports, studies, base cases, drawings, findings, manuals, procedures and recommendations prepared by PCFS Solutions or its suppliers, licensors or subcontractors in the course of performing the Professional Services. Materials means all content and other items included with or as part of the Professional Services, Software or Deliverables. Professional Services means the services performed by PCFS Solutions as described in one or more Statements of Work. Software means any software, library, utility, tool, or other computer or program code, in object (binary) or source-code form, as well as the related documentation, provided by PCFS Solutions to you in connection with the Professional Services. Software includes software locally installed on your systems and software accessed by you through the Internet or other remote means (such as websites, portals, the PCFS Solutions Platform, and cloud-based solutions). Statements of Work are separately signed mutually agreed upon documents that outline the scope of the Professional Services, time period for service delivery (including any milestone requirements), requisite service steps, and payment terms. Third-Party Products means any non-PCFS Solutions-branded products, software or services. C. Additional Agreements. This Agreement together with any accompanying Statements of Work, forms a legally binding contract between you and PCFS Solutions in relation to your purchase and PCFS Solutions performance of Professional Services. Each Statement of Work will be interpreted as a single agreement, independent of any other Statement of Work, so that all of the provisions are given as full effect as possible. In the event of a conflict between these agreements, the terms of these documents will be interpreted in the following order of precedence: (1) Statement of Work; (2) this Agreement. D. Payment. I. Payment Terms. Unless otherwise agreed to by PCFS Solutions, payment of invoices must be received by prior to commencement of the Professional Services. Client will pay PCFS Solutions fees for the Professional Services calculated using the rates set forth in the Statement of Work within 30 days after receiving invoice(s) for such fees. 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PCFS Solutions further reserves the right to seek collection of all overdue amounts (including by referral to third-party collectors), plus all reasonable legal fees (including reasonable attorneys fees) and costs associated with such collection, and Client agrees to pay the same. III. Taxes. Unless otherwise expressly stated, any fees charged to Client do not include Taxes (as defined below). Client is required to pay any and all Taxes associated with the fees charged by PCFS Solutions (Transaction Taxes), regardless of how or upon whom they are imposed on. These Transaction Taxes exclude income taxes but may include, but are not limited to, local, state, provincial, federal or foreign taxes, levies, duties or similar governmental assessments of any nature, including value added taxes, consumption taxes, Goods and Services taxes, GST/HST, excise, sales, use or similar taxes and any withholding taxes (together Taxes). 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In connection with this Agreement, each party may have access to or be exposed to information of the other party that is not generally known to the public, such as Software, Materials, product plans, pricing, marketing and sales information, Client lists, know-how, or trade secrets, which may be designated as confidential or which, under the circumstances surrounding disclosure, should be treated as confidential (collectively, Confidential Information). Confidential Information may not be shared with third parties unless such disclosure is to the receiving partys personnel, including employees, agents and subcontractors, on a need-to-know basis in connection with this Agreement, so long as such personnel have agreed in writing to treat such Confidential Information under terms at least as restrictive as those herein. Each party agrees to take the necessary precautions to maintain the confidentiality of the other partys Confidential Information by using at least the same degree of car e as such party employs with respect to its own Confidential Information of a similar nature, but in no case less than a commercially reasonable standard of care to maintain confidentiality. The foregoing shall not apply to information that (1) was known by one party prior to its receipt from the other or is or becomes public knowledge through no fault of the recipient; or (2) is rightfully received by the recipient from a third party without a duty of confidentiality. If a recipient is required by a court or government agency to disclose Confidential Information, the recipient shall provide advance notice to other party before making such a disclosure. The obligations with respect to Confidential Information shall continue for two years from the date of disclosure. 4. Term; Termination. A. Term of this Agreement. This Agreement shall be effective from the Effective Date and shall continue until it is terminated as set forth below (the Term). B. Termination. Either party may terminate an individual Statement of Work hereunder if the other party commits a material breach of such agreement and the breach is not cured within 90 days of receipt of written notice from the injured party. PCFS Solutions may terminate this Agreement immediately, if (1) you fail to make any payment when due; (2) you are acquired by or merge with a competitor of PCFS Solutions; (3) you declare bankruptcy or are adjudicated bankrupt; or (4) a receiver or trustee is appointed for you or substantially all of your assets. Either party may terminate this agreement with (30) days written notice provided as set forth in Section 9(N). Upon termination of this Agreement, all rights and obligations of the parties under this Agreement and any accompanying Statements of Work will automatically terminate except for rights of action accruing prior to termination, payment obligations accruing pursuant to any Statements of Work, and any obligations that expressly or by implicatio n are intended to survive termination. 5. Proprietary Rights. You irrevocably acknowledge that, subject to the license granted herein or any separate license agreement referenced in Section 8 below, you have no ownership interest in the Software, the Materials, the methods by which the Professional Services are performed or the processes that make up the Professional Services (the PCFS Solutions IP). PCFS Solutions owns all right, title and interest in the PCFS Solutions IP, subject to any limitations associated with the intellectual property rights of third parties. PCFS Solutions reserves all rights not specifically granted herein. 6. Deliverables. Subject to payment in full for the applicable Professional Services, PCFS Solutions grants you a non-exclusive, non-transferable, royalty-free right to use the Deliverables solely in the country or countries in which you do business, solely for your internal use, and solely as necessary for you to enjoy the benefit of the Professional Services as stated in the applicable Statements of Work. PCFS Solutions and its applicable suppliers or licensors will retain exclusive ownership of all Deliverables, and will own all intellectual property rights, title and interest in any ideas, concepts, know-how, documentation and techniques associated with such Deliverables. 7. Suspension or Modification of Software or Professional Services. PCFS Solutions may suspend, terminate, withdraw or discontinue all or part of the Professional Services or your access or one or more users access to the Software upon receipt of a subpoena or law-enforcement request, or when PCFS Solutions believes, in its sole discretion, that you (or your users) have breached any term of this Agreement or an applicable Statement of Work or are involved in any fraudulent, misleading or illegal activities. 8. Software. A. Accompanying License. Software and Materials may be provided subject to a separate software license agreement, product guides, operating manuals or other documentation included with the software or presented to you during the installation or use of the Software. You agree to be bound by such license agreements. B. Software License from PCFS Solutions. If no license terms accompany the Software, then subject to your compliance with the terms set forth in this Agreement, PCFS Solutions hereby grants you a personal, nonexclusive license to access and use such Software only during the term of the Professional Services and solely as necessary for you to enjoy the benefit of the Professional Services as stated in the applicable Statement of Work. I. Restrictions. You may not copy, modify or create a derivative work, collective work or compilation of the Software, and may not reverse engineer, decompile or otherwise attempt to extract the code of the Software or any part thereof. You may not license, sell, assign, sublicense or otherwise transfer or encumber the Software; may not use the Software in your own delivery of managed-services to third-parties or in a service bureau arrangement; and may not use the Software in excess  of the authorized number of licensed seats for concurrent users, sites or other criteria specified in the applicable Statements of Work. In addition, Client may not access the Software or monitor its availability, performance or functionality, or for any other benchmarking or competitive purpose.You are further prohibited from (1) attempting to use or gain unauthorized access to PCFS Solutions networks or equipment; (2) permitting other individuals or entities to use the Software or copy the Software or Professional Services; (3) attempting to probe, scan or test the vulnerability of Software or a system, account or network of PCFS Solutions or any of its Clients or suppliers; (4) interfering or attempting to interfere with service to any user, host or network; (5) transmitting unsolicited bulk or commercial messages; (6) restricting, inhibiting or otherwise interfering with the ability of any other person, regardless of intent, purpose or knowledge, to use or enjoy the Software (except for tools with safety and security functions); or (7) restricting, inhibiting, interfering with or otherwise disrupting or causing a performance degradation to any PCFS Solutions facilities used to deliver the Professional Services. II. Audit. You hereby grant PCFS Solutions, or an agent designated by PCFS Solutions, the right to perform an audit of your use of the Software during normal business hours; you agree to cooperate with PCFS Solutions in such audit; and you agree to provide PCFS Solutions with all records reasonably related to your use of the Software. The audit will be limited to verification of your compliance with the software licensing terms of this Agreement. 9. Additional Terms. A. Limited Warranty. PCFS SOLUTIONS WARRANTS THAT ITS SERVICES SHALL BE PERFORMED BY QUALIFIED PERSONNEL IN A MANNER CONSISTENT WITH GOOD PRACTICE IN THE INFORMATION TECHNOLOGY SERVICES INDUSTRY. IF PCFS SOLUTIONS BREACHES THIS WARRANTY, IT SHALL SUPPLY SERVICES TO CORRECT OR REPLACE THE WORK AT NO CHARGE. THE REMEDY SET FORTH IN THIS SECTION IS CLIENTS EXCLUSIVE REMEDY FOR BREACH OF WARRANTY. PCFS SOLUTIONS WARRANTS THAT IT HAS THE RIGHT TO GRANT THE LICENSES TO THE SOFTWARE LICENSED IN SECTION 8 ABOVE, AND SUCH SOFTWARE WILL SUBSTANTIALLY CONFORM TO THE FUNCTIONAL SPECIFICATIONS AND CURRENT DOCUMENTATION PROVIDED BY PCFS SOLUTIONS. THIS WARRANTY DOES NOT COVER SERVICE NOT PERFORMED OR AUTHORIZED BY PCFS SOLUTIONS (INCLUDING INSTALLATION OR DE-INSTALLATION), USAGE NOT IN ACCORDANCE WITH SOFTWARE INSTRUCTIONS, OR USE OF PARTS AND COMPONENTS NOT SUPPLIED OR INTENDED FOR USE WITH THE SOFTWARE OR SERVICES. EXCEPT AS EXPRESSLY STATED IN THE THIS SECTION 9(A), PCFS SOLUTIONS, (INCLUDING ITS AFFILIATES, CONTRACTORS, AND AGENTS, AND EACH OF THEIR RESPECTIVE EMPLOYEES, DIRECTORS, AND OFFICERS), ON BEHALF OF ITSELF AND ITS SUPPLIERS (COLLECTIVELY, THE PCFS SOLUTIONS PARTIES) MAKES NO EXPRESS OR IMPLIED WARRANTY WITH RESPECT TO ANY OF THE SOFTWARE OR SERVICES, INCLUDING BUT NOT LIMITED TO ANY WARRANTY (1) OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, PERFORMANCE, SUITABILITY OR NON-INFRINGEMENT; (2) RELATING TO THIRD-PARTY PRODUCTS; (3) RELATING TO THE PERFORMANCE OF SOFTWARE OR PCFS SOLUTIONSS PERFORMANCE OF THE SERVICES OR WHETHER THE SOFTWARE OR SERVICES ARE SUITABLE FOR HIGH-RISK ACTIVITIES; OR (4) REGARDING THE RESULTS TO BE OBTAINED FROM THE SOFTWARE OR SERVICES OR THE RESULTS OF ANY RECOMMENDATION BY PCFS SOLUTIONS. B. Limitation of Liability. TO THE EXTENT PERMISSIBLE BY LAW, PCFS SOLUTIONS WILL NOT BE LIABLE FOR ANY INCIDENTAL, INDIRECT, PUNITIVE, SPECIAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF OR IN CONNECTION WITH THE SOFTWARE OR SERVICES PROVIDED HEREUNDER. EXCEPT FOR YOUR BREACH OF SECTION 1.D.I. OR SECTION 8, OR ANY CLAIM BROUGHT PURSUANT TO SECTION 9(C), NEITHER PARTY SHALL HAVE LIABILITY FOR THE FOLLOWING: (1) LOSS OF REVENUE, INCOME, PROFIT OR SAVINGS; (2) LOST OR CORRUPTED DATA OR SOFTWARE, LOSS OF USE OF A SYSTEM OR NETWORK OR THE RECOVERY OF SUCH; (3) LOSS OF BUSINESS OPPORTUNITY, GOODWILL OR REPUTATION; (4) BUSINESS INTERRUPTION OR DOWNTIME; OR (5) DELIVERABLES OR THIRD-PARTY PRODUCTS NOT BEING AVAILABLE FOR USE. IN NO CIRCUMSTANCES, SHALL PCFS SOLUTIONSS TOTAL LIABILITY FOR ANY AND ALL CLAIMS ARISING OUT OF OR IN CONNECTION WITH THIS AGREEMENT EXCEED THE TOTAL AMOUNT PAID BY CLIENT TO PCFS SOLUTIONS UNDER THE APPLICABLE STATEMENT OF WORK. THESE LIMITATIONS, EXCLUSIONS AND DISCLAIMERS SHALL APPLY TO ALL CLAIMS FOR DAMAGES, WHETHER BASED IN CONTRACT, WARRANTY, STRICT LIABILITY, NEGLIGENCE, TORT OR OTHERWISE. THE PARTIES AGREE THAT THESE LIMITATIONS OF LIABILITY ARE AGREED ALLOCATIONS OF RISK CONSTITUTING IN PART THE CONSIDERATION FOR PCFS SOLUTIONSS SALE OF SOFTWARE OR SERVICES TO CLIENT, AND SUCH LIMITATIONS WILL APPLY NOTWITHSTANDING THE FAILURE OF ESSENTIAL PURPOSE OF ANY LIMITED REMEDY AND EVEN IF A PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH LIABILITIES. C. Indemnification. PCFS Solutions shall defend and indemnify you against any third-party claim or action that Software, Professional Services or Deliverables (excluding Third-Party Products and open source software) prepared or produced by PCFS Solutions and delivered pursuant to this Agreement infringe or misappropriate that third partys U.S. patent, copyright, trade secret, or other intellectual property rights (Indemnified Claims). In addition, if PCFS Solutions receives prompt notice of an Indemnified Claim that, in PCFS Solutionss reasonable opinion, is likely to result in an adverse ruling, then PCFS Solutions shall, at its option, (1) obtain a right for you to continue using such Software, Deliverables or allow PCFS Solutions to continue performing the Professional Services; (2) modify such Software, Professional Services or Deliverables to make them non-infringing; (3) replace such Software, Professional Services or Deliverables with a non-infringing equivalent; or (4) refund any pre-paid fees for the allegedly infringing Professional Services that have not been performed or provide a reasonable depreciated or pro rata refund for the allegedly infringing Product, Deliverables or Software. Notwithstanding the foregoing, PCFS Solutions shall have no obligation under this Section for any claim resulting or arising from (1) modifications of the Software, Professional Services, or Deliverables that were not performed by or on behalf of PCFS Solutions; (2) the combination, operation, or use of the Software, Professional Services or Deliverables in connection with a Third- Party Product (the combination of which causes the claimed infringement); or (3) PCFS Solutionss compliance with your written specifications or directions, including the incorporation of any software or other materials or processes provided by or requested by you. PCFS Solutionss duty to indemnify and defend under this Section 9.C. is contingent upon: (1) PCFS Solutions receiving prompt written notice an Indem nified Claim, (2) PCFS Solutions having the right to solely control the defense and resolution of such Indemnified Claim, and (3) your cooperation with PCFS Solutions in the defense and resolution of such Indemnified Claim. This Section 9.C. states Clients exclusive remedies for any third-party intellectual property claim or action, and nothing in this Agreement or elsewhere will obligate PCFS Solutions to provide any greater indemnity to Client. You shall defend and indemnify PCFS Solutions against any third-party claim or action arising out of (1) your failure to obtain any appropriate license, intellectual property rights, or other permissions, regulatory certifications, or approvals associated with technology or data provided by you, or associated with software or other components directed or requested by you to be installed or integrated as part of the Software, Professional Services or Deliverables; (2) your breach of this Agreement; (3) any inaccurate representation regarding the existence of an export license or any allegation made against PCFS Solutions due to your violation or alleged violation of applicable export laws, regulations, or orders; or (4) your providing of (or providing access to) Excluded Data (defined below) to PCFS Solutions. Each party shall defend and indemnify the other party against any third-party claim or action for personal bodily injury, including death, to the extent directly caused by the indemnifying partys gross negligence or willful misconduct in the course of performing its obligations under this Agreement. D. Independent Contractor Relationship; Assignment; Subcontracting. The parties are independent contractors. No provision of this Agreement will or shall be deemed to create an association, trust, partnership, joint venture or other entity or similar legal relationship between PCFS Solutions and Client, or impose a trust, partnership or fiduciary duty, obligation, or liability on or with respect to such entities. Neither party will have any rights, power or authority to act or create an obligation, express or implied, on behalf of another party except as specified in this Agreement. PCFS Solutions has the right to assign, subcontract or delegate in whole or in part this Agreement, or any rights, duties, obligations or liabilities under this Agreement, by operation of law or otherwise, provided that PCFS Solutions shall remain responsible for the performance of Professional Services under this Agreement. Otherwise, neither party may assign this Agreement, in whole or in part, without the permission of the other. E. Force Majeure. Neither party shall be liable to the other for any failure to perform any of its obligations (except payment obligations) under this Agreement during any period in which such performance is delayed by circumstances beyond its reasonable control, such as fire, flood, war, cyber warfare, including, but not limited to, Internet-based conflict and attacks on information systems designed to or resulting in the disabling of websites and networks, embargo, strike, riot or the intervention of any governmental authority (a Force Majeure). In such event, however, the delayed party must promptly provide the other party with written notice of the Force Majeure. The delayed partys time for performance will be excused for the duration of the Force Majeure, but if the Force Majeure event lasts longer than 30 days, then the other party may immediately terminate, in whole or in part, this Agreement or the applicable Statement of Work by giving written notice to the delayed party. G. Entire Agreement; Severability. This Agreement, together with any Statement of Work, is the entire agreement between you and PCFS Solutions with respect to its subject matter and supersedes all prior oral and written understandings, communications, or agreements between you and PCFS Solutions. No amendment to or modification of this Agreement, in whole or in part, will be valid or binding unless it is in writing and executed by authorized representatives of both parties. If any provision of this Agreement should be found to be void or unenforceable, such provision will be stricken or modified, but only to the extent necessary to comply with the law, and the remainder of this Agreement will remain in full force and will not be terminated. H. Governing Law. This Agreement, any related Statement of Work, and ANY CLAIM, DISPUTE OR CONTROVERSY (WHETHER IN CONTRACT, TORT, OR OTHERWISE, INCLUDING STATUTORY, CONSUMER PROTECTION, COMMON LAW, INTENTIONAL TORT AND EQUITABLE CLAIMS) BETWEEN CLIENT AND PCFS SOLUTIONS, including their affiliates, contractors and agents, and each of their respective employees, directors and officers arising from or relating to this Agreement, its interpretation, or the breach, termination or validity thereof, the relationships which result from this Agreement (including, to the full extent permitted by applicable law, relationships with third parties who are not signatories to this Agreement) any related purchase (a Dispute) shall be governed by the laws of the State of California, without regard to conflicts of law. I. Venue. The parties agree that any Dispute shall be brought exclusively in the state or federal courts located in Orange County, California. Client and PCFS Solutions agree to submit to the personal jurisdiction of the state and federal courts located within Orange County, California, and agree to waive any and all objections to the exercise of jurisdiction over the parties by such courts and to venue in such courts. J. Bench Trial. The parties agree to waive, to the maximum extent permitted by law, any right to a jury trial with respect to any Dispute. K. No Class Actions. NEITHER CLIENT NOR PCFS SOLUTIONS SHALL BE ENTITLED TO JOIN OR CONSOLIDATE CLAIMS BY OR AGAINST OTHER CLIENTS, OR PURSUE ANY CLAIM AS A REPRESENTATIVE OR CLASS ACTION OR IN A PRIVATE ATTORNEY GENERAL CAPACITY. L. Limitation Period. NEITHER PARTY SHALL BE LIABLE FOR ANY CLAIM BROUGHT MORE THAN TWO YEARS AFTER THE CAUSE OF ACTION FOR SUCH CLAIM FIRST AROSE. M. Dispute Resolution. Client and PCFS Solutions will attempt to resolve any Dispute through face-to-face negotiation with persons fully authorized to resolve the Dispute or through mediation utilizing a mediator agreed to by the parties, rather than through litigation. The existence or results of any negotiation or mediation will be treated as confidential. Notwithstanding the foregoing, either party will have the right to obtain from a state or federal court in Orange County a temporary restraining order, preliminary injunction, or other equitable relief to preserve the status quo, prevent irreparable harm, avoid the expiration of any applicable limitations period, or preserve a superior position with respect to other creditors, although the merits of the underlying Dispute will be resolved in accordance with this paragraph. In the event the parties are unable to resolve the Dispute within 30 days of notice of the Dispute to the other party, the parties shall be free to pursue all remedies available at l aw or in equity. N. Scope of Services. Subject to the terms and conditions of this Agreement, Company will perform those services (Services) with respect to the Company products separately purchased by Client (Company Commercially-Available Software) as set forth in one or supplemental document(s) (Statement of Work), attached hereto as Exhibit A and as amended and/or supplemented from time to time by the mutual written agreement of the parties and incorporated herein by reference. A Statement of Work will be, at a minimum, a written document that (i) references this Agreement, (ii) describes the Services to be performed (and if said Services shall include the creation of object code, such object Code is defined herein as Deliverable), (iii) specifies the corresponding rate schedule or other fee information, and (iv) is signed by both parties or is issued by one party and signed by the other party. Company will use commercially reasonable efforts to complete the Services by the applicable dates set forth in the attachment (Target Dates). O. Change Orders. Any changes to the scope of the Services must be made in writing and signed by both parties (Change Order) or if the Change Order is made via email to the other partys designated contact person, the receiving party will have five business days to reject the Change Order. If said rejection is not made within the 5 business day period, the Change Order is deemed mutually accepted. Each accepted Change Order will be incorporated herein by reference and subject to the terms and conditions of this Agreement. P. Execution This Agreement may be executed and delivered by facsimile/PDF and the parties agree that such facsimile execution and delivery will have the same force and effect as delivery of an original document with original signatures, and that each party may use such facsimile signatures as evidence of the execution and delivery of this Agreement by all parties to the same extent that an original signature could be used. IN WITNESS WHEREOF, the parties by their duly authorized representatives have executed this Agreement as of the Effective Date.